Phenotypes Associated with This Genotype

Genotype
MGI:3796834

• Allelic Composition: Tg(FLII)1Hdc/0
• Genetic Background: involves: BALB/cJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

delayed wound healing ( J:119983 )

• wound areas are significantly larger in transgenic mice than controls at 3 and 7 days post-wounding

• wound length and dermal gape are increased relative to controls at 3 and 7 days after wounding

• scratch wounds in confluent fibroblast cultures close faster in wild-type cultures than in transgenic cultures

impaired wound healing ( J:119983 )

• wound length and dermal gape are increased relative to controls at 3 and 7 days after wounding

• length of neoepidermis is similar to controls, but percentage of re-epithelialization at 3 days after wounding is significantly decreased

• cell proliferation within epidermis of wounds is similar in wild-type, Flii-deficient heterozygous mice and transgenic mice, but significantly fewer proliferating cells are detected in dermis of wounds in transgenic mice at 7 days after wounding