Phenotypes Associated with This Genotype

Genotype
MGI:3796527

• Allelic Composition: Ednra^{tm3(Ednrb)Hku}/Ednra^{tm3(Ednrb)Hku}
• Genetic Background: involves: 129 * C57BL/6 * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:131382 )

craniofacial

abnormal craniofacial bone morphology ( J:131382 )

• ectopic cartilage appears between malleal/incal region and the extended basitrabecular process and/or ala temporalis at E18.5

abnormal hyoid bone morphology ( J:131382 )

• hyoid in some mutants is fused only unilaterally to basisphenoid bone or separated from basisphenoid

• bone typically shows extended ossification center and connects to stapes through a transformed lesser horn

abnormal mandible morphology ( J:131382 )

• abnormalities similar to Ednra^tm2Hku/Ednra^{tm3(Ednrb)Hku} compound mutants at E18.5

• mice have relatively well-developed incisive alveolus

skeleton

abnormal craniofacial bone morphology ( J:131382 )

• ectopic cartilage appears between malleal/incal region and the extended basitrabecular process and/or ala temporalis at E18.5

abnormal hyoid bone morphology ( J:131382 )

• hyoid in some mutants is fused only unilaterally to basisphenoid bone or separated from basisphenoid

• bone typically shows extended ossification center and connects to stapes through a transformed lesser horn

abnormal mandible morphology ( J:131382 )

• abnormalities similar to Ednra^tm2Hku/Ednra^{tm3(Ednrb)Hku} compound mutants at E18.5

• mice have relatively well-developed incisive alveolus