Phenotypes Associated with This Genotype

Genotype
MGI:3796526

• Allelic Composition: Ednra^tm2.1Hku/Ednra^{tm3(Ednrb)Hku}
• Genetic Background: involves: 129 * C57BL/6 * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:131382 )

• animals die at birth

craniofacial

abnormal craniofacial bone morphology ( J:131382 )

• ectopic cartilage appears between malleal/incal region and the extended basitrabecular process and/or ala temporalis

abnormal hyoid bone morphology ( J:131382 )

• hyoid in some mutants is fused only unilaterally to basisphenoid bone

• bone typically shows extended ossification center and connects to stapes through a transformed lesser horn

abnormal mandible morphology ( J:131382 )

• at E10.5, apoptosis extending from proximal to distal mandibular region, but is confined to proximal region in wild-type

lower jaw to upper jaw transformation ( J:131382 )

• lower jaw is mirror image of upper jaw with arrays of vibrissae at E18.5

• skeletal analysis shows duplication of upper jaw elements in lower jaw region

skeleton

abnormal craniofacial bone morphology ( J:131382 )

• ectopic cartilage appears between malleal/incal region and the extended basitrabecular process and/or ala temporalis

abnormal hyoid bone morphology ( J:131382 )

• hyoid in some mutants is fused only unilaterally to basisphenoid bone

• bone typically shows extended ossification center and connects to stapes through a transformed lesser horn

abnormal mandible morphology ( J:131382 )

• at E10.5, apoptosis extending from proximal to distal mandibular region, but is confined to proximal region in wild-type

lower jaw to upper jaw transformation ( J:131382 )

• lower jaw is mirror image of upper jaw with arrays of vibrissae at E18.5

• skeletal analysis shows duplication of upper jaw elements in lower jaw region

growth/size/body

abnormal hyoid bone morphology ( J:131382 )

• hyoid in some mutants is fused only unilaterally to basisphenoid bone

• bone typically shows extended ossification center and connects to stapes through a transformed lesser horn

abnormal mandible morphology ( J:131382 )

• at E10.5, apoptosis extending from proximal to distal mandibular region, but is confined to proximal region in wild-type

lower jaw to upper jaw transformation ( J:131382 )

• lower jaw is mirror image of upper jaw with arrays of vibrissae at E18.5

• skeletal analysis shows duplication of upper jaw elements in lower jaw region