Phenotypes Associated with This Genotype

Genotype
MGI:3796424

• Allelic Composition: Tg(Camk2a-Gpr85)1Mima/?
• Genetic Background: involves: C57BL/6 * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal contextual conditioning behavior ( J:134303 )

• a fear conditioning task reveals that mice fail to remember the fear conditioning stimulus delivered 24 hours earlier

abnormal whisker trimming behavior ( J:134303 )

• mice have increased length of whiskers resulting from less trimming by littermates

• when housed with with wild-type littermates, whisker length is normal

abnormal social investigation ( J:134303 )

• the mean number of social interactions that occur in a 10 minute span are reduced from 63.5 to 52.6

nervous system

increased neuron apoptosis ( J:134303 )

• excess neuronal apoptosis occurs in the forebrain during the first two weeks of life

abnormal brain size ( J:134303 )

• whole-brain parenchyma volume is reduced by 20% while ventricular volume is significantly increased

decreased brain weight ( J:134303 )

• 5 month old mice have about a 20% reduction in brain weight compared to control mice

• differences in brain weight are first observed in 10 days after birth

abnormal cerebral cortex morphology ( J:134303 )

• neurons in the cerebral cortices are smaller and more tightly packed

abnormal dendrite morphology ( J:134303 )

• neurons in the brain have fewer dendrtiic arborizations

abnormal paired-pulse inhibition ( J:134303 )

• mice have decreased reductions in startle response when subjected to pre-pulses of 76dB and 82dB

growth/size/body

decreased body weight ( J:134303 )

• the mean body weight of 5 month old female mice is one gram less than age-matched wild-type mice

cellular

increased neuron apoptosis ( J:134303 )

• excess neuronal apoptosis occurs in the forebrain during the first two weeks of life