Phenotypes Associated with This Genotype

Genotype
MGI:3796419

• Allelic Composition: Mxd1^tm1Rne/Mxd1^tm1Rne
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:45945 )

N • mice produce normal levels of serum immunoglobulins and show no increased level of spontaneous infection when housed in non-pathogen-free conditions

abnormal myeloid leukocyte morphology ( J:45945 )

• myeloid clls from bone marrow show increased sensitivity to apoptosis-inducing stimuli and decreased survival ability under limiting cytokine conditions compared to wild-type

increased granulocyte number ( J:45945 )

• increased frequency of mature granulocytes in bone marrow of mutants compared to wild-type

• increased frequency (3-fold) of granulocytic cluster-forming cells bone marrow culture stimulated with G-CSF

• after 5-fluorouracil ablation of proliferating bone marrow precursors, mature peripheral blood and splenic granulocyes recover to higher levels than in wild-type by 14 days post-treatment, and increased numbers of granulocyte cluster-forming cells are found in bone marrow and spleen

abnormal B cell physiology ( J:45945 )

• in vitro stimulation with LPS results in resting B lymphocytes re-entering the cell cycle more rapidly than wild-type cells

hematopoietic system

abnormal common myeloid progenitor cell morphology ( J:45945 )

• frequency of granulocytic precursors of promyelocyte/myelocyte morphology is increased in bone marrow compared to wild-type

abnormal myeloid leukocyte morphology ( J:45945 )

• myeloid clls from bone marrow show increased sensitivity to apoptosis-inducing stimuli and decreased survival ability under limiting cytokine conditions compared to wild-type

increased granulocyte number ( J:45945 )

• increased frequency of mature granulocytes in bone marrow of mutants compared to wild-type

• increased frequency (3-fold) of granulocytic cluster-forming cells bone marrow culture stimulated with G-CSF

• after 5-fluorouracil ablation of proliferating bone marrow precursors, mature peripheral blood and splenic granulocyes recover to higher levels than in wild-type by 14 days post-treatment, and increased numbers of granulocyte cluster-forming cells are found in bone marrow and spleen

abnormal B cell physiology ( J:45945 )

• in vitro stimulation with LPS results in resting B lymphocytes re-entering the cell cycle more rapidly than wild-type cells