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Phenotypes Associated with This Genotype
Genotype
MGI:3796152
Allelic
Composition		 Mirc2tm1.1Tyj/Y
Mirc3tm1.1Tyj/Mirc3tm1.1Tyj
Mirc1tm1.2Tyj/Mirc1tm1.2Tyj
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc1tm1.2Tyj mutation (1 available); any Mirc1 mutation (6 available)
Mirc2tm1.1Tyj mutation (1 available); any Mirc2 mutation (1 available)
Mirc3tm1.1Tyj mutation (1 available); any Mirc3 mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:134861 )
• embryos die before E15

cardiovascular system
atrial septal defect ( J:134861 )
• defective atrial and ventricular septation at E13.5 and E14.5
ventricular septal defect ( J:134861 )
• defective atrial and ventricular septation at E13.5 and E14.5
thin ventricular wall ( J:134861 )
• ventricles are thinner than in wild-type at E13.5 and 14.5

cellular
increased apoptosis ( J:134861 )
• increased apoptosis is seen at E14.5 in fetal liver, ventral horns of spinal cord, and lateral ganglionic eminences

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory