Phenotypes Associated with This Genotype

Genotype
MGI:3796151

• Allelic Composition: Mirc3^tm1.1Tyj/Mirc3^tm1.1Tyj; Mirc1^tm1.2Tyj/Mirc1^tm1.2Tyj
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:134861 )

• embryos die before E15

cardiovascular system

blood vessel congestion ( J:134861 )

• at E13.5 and 14.5

atrial septal defect ( J:134861 )

• defective atrial and ventricular septation at E13.5 and E14.5

ventricular septal defect ( J:134861 )

• defective atrial and ventricular septation at E13.5 and E14.5

thin ventricular wall ( J:134861 )

• ventricles are thinner than in wild-type at E13.5 and 14.5

cellular

increased apoptosis ( J:134861 )

• increased apoptosis is seen at E14.5 in fetal liver, ventral horns of spinal cord, and lateral ganglionic eminences

homeostasis/metabolism

edema ( J:134861 )

• at E13.5 and 14.5