Phenotypes Associated with This Genotype

Genotype
MGI:3796144

• Allelic Composition: Mirc1^tm1.2Tyj/Mirc1^tm1.2Tyj
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:134861 )

• no viable homozygotes are produced from heterozygous intercrosses; homozygous phenotype is indistinguishable from Mirn17-92^tm1.3Tyj homozygotes

embryo

decreased embryo size ( J:134861 )

• at E13.5, mutants can be distinguished by their smaller size

decreased embryo weight ( J:134861 )

• by E18.5, mutant weights are 60% of wild-type littermates

growth/size/body

decreased embryo size ( J:134861 )

• at E13.5, mutants can be distinguished by their smaller size

decreased embryo weight ( J:134861 )

• by E18.5, mutant weights are 60% of wild-type littermates

cardiovascular system

abnormal interventricular septum morphology ( J:134861 )

respiratory system

pulmonary hypoplasia ( J:134861 )

• E18.5-P0 animals have severely hypoplastic lungs but histological examination does not reveal any branching defect or other developmental abnormalities

hematopoietic system

increased B cell apoptosis ( J:134861 )

• mutant fetal livers display increased apoptosis specific to the B cell compartment without higher levels in non-B cells

• higher levels of apoptosis are not observed in other organs

abnormal B cell differentiation ( J:134861 )

• lethally irradiated mice transplanted with E14.5 mutant liver cells are found to have reduced percentages of pre-B cells and cells of later stages

decreased pre-B cell number ( J:134861 )

• fetal livers (E18.5) show a greatly reduced percentage and absolute number of pre-B cells

immune system

increased B cell apoptosis ( J:134861 )

• mutant fetal livers display increased apoptosis specific to the B cell compartment without higher levels in non-B cells

• higher levels of apoptosis are not observed in other organs

abnormal B cell differentiation ( J:134861 )

• lethally irradiated mice transplanted with E14.5 mutant liver cells are found to have reduced percentages of pre-B cells and cells of later stages

decreased pre-B cell number ( J:134861 )

• fetal livers (E18.5) show a greatly reduced percentage and absolute number of pre-B cells

cellular

increased B cell apoptosis ( J:134861 )

• mutant fetal livers display increased apoptosis specific to the B cell compartment without higher levels in non-B cells

• higher levels of apoptosis are not observed in other organs