Phenotypes Associated with This Genotype

Genotype
MGI:3796055

• Allelic Composition: Otx2^{tm5(OTX2)Asim}/Otx2^{tm5(OTX2)Asim}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal forebrain development ( J:72726 )

• forebrain patterning is similar to that observed in Otx2^tm3(otd)Asim homozygotes based on marker expression

abnormal midbrain development ( J:72726 )

• forebrain patterning is similar to that observed in Otx2^tm3(otd)Asim homozygotes based on marker expression

growth/size/body

abnormal head morphology ( J:72726 )

• a low percentage (4.7%) exhibit a 'headless' phenotype, while the remainder show mild, moderate, or severe phenotypes at 10.5 days post coitum (dpc)

acephaly ( J:72726 )

• a low percentage (4.7%) exhibit a 'headless' phenotype