Phenotypes Associated with This Genotype

Genotype
MGI:3795907

• Allelic Composition: Src^tm1Sor/Src^tm1Sor; Yes1^tm1Sor/Yes1^tm1Sor
• Genetic Background: involves: 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:20346 )

• some animals survived past weaning age; one survived to one year of age on a soft food diet

neonatal lethality, incomplete penetrance ( J:20346 )

• incomplete penetrance; only 10% of animals survived to weaning age; normal Mendelian ratios were present at E18.5, but many were found dead shortly after birth

growth/size/body

decreased body size ( J:20346 )

• embryos at E18.5 were approximately 25% smaller than controls despite normal placenta morphology

respiratory system

abnormal breathing pattern ( J:20346 )

• animals delivered by Cesarean at E18.5 only started to breathe normally after one hour of prodding

skeleton

osteopetrosis ( J:20346 )

• no more severe than in homozygous Src mutant mice