Analysis Tools
cellular
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• T. congolense parasite infection leads to higher apoptosis in the liver among both CD11b- and CD11b+ cells
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behavior/neurological
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• of male and female mice fed a standard diet in a Morris water maze
• however, mice fed a high selenium diet exhibit normal learning
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• in male and female mice
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• mice exhibit motor deficits compared with wild-type mice
• however, selenium supplementation alleviates motor deficits
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• in a pole test and inverted hang test
• worse in males than females
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• male, but not female, mice hang upside-down on a vertically oriented pole for less time than wild-type mice
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• mice have stride lengths that are significantly shorter than control mice
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• in male mice but not female mice
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• greatly in males
• slightly in females
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immune system
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• mice are more susceptible to T. congolense infection with a significantly higher parasite burden in the blood six days after infection and a significantly decreased survival curve
• 50% of mice die around 9 days post infection while 50% of control mice survive until 150 days
• mice that survive the initial infection die significantly earlier than controls (around 95 days post infection vs 163 days in controls)
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homeostasis/metabolism
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• selenium plasma levels are on average less than half that of wild-type controls
• whole body selenium levels are decreased by 36%
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liver/biliary system
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• T. congolense parasite infection leads to higher apoptosis in the liver among both CD11b- and CD11b+ cells
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• there is decreased liver function compared to wild-type mice 9 days post infection with T. congolense parasite infection
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mortality/aging
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• mice die of nuerological dysfunctions within 30 days of removal from selenium in the diet
• the survival curve is significantly shorter than Sepp1tm2Rfb mice on a selenium deficient diet
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