Phenotypes Associated with This Genotype

Genotype
MGI:3795753

• Allelic Composition: Plxna2^tm1Hfu/Plxna2^tm1Hfu
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal neuronal migration ( J:135408 )

• about 1/3 of labeled granule cells remain in the external granule layer 36 h after a BrdU injection

• the number of migrating cells and maximum migration distance are reduced in external granule layer explants

• in migrating granule cells the average distance between the centrosome and nucleus is increased and more variable

abnormal hippocampal mossy fiber morphology ( J:160509 )

• mossy fiber terminate at the proximal parts of the infrapyramidal region and stratum and fail to innervate into the suprapyramidal region unlike in wild-type mice

• mice lack a suprapyramidal bundle unlike wild-type mice

ectopic cerebellar granule cells ( J:135408 )

• about 40% of granule cells remain in the molecular layer in the adult cerebellum

• ectopic cells are still innervated by mossy fibers, neurite outgrowth from granule cells is normal and Purkinje cell differentiation is normal

vision/eye

vision/eye phenotype ( J:172268 )

N • mice exhibit normal retinal stratification

cellular

abnormal neuronal migration ( J:135408 )

• about 1/3 of labeled granule cells remain in the external granule layer 36 h after a BrdU injection

• the number of migrating cells and maximum migration distance are reduced in external granule layer explants

• in migrating granule cells the average distance between the centrosome and nucleus is increased and more variable