Mouse Genome Informatics
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    Pkd1tm2Som/Pkd1tm2.1Som
Tg(Cdh16-cre)91Igr/0

involves: C57BL/6 * ICR * SJL
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• mice die between P14 and P17 of renal failure

renal/urinary system
• at P7, proliferation of the cyst lining cells in the kidney is increased compared to in wild-type mice
• an increased kidney weight to body weight ratio is observed at day 4 and increases rapidly thereafter
• mice exhibit a rapid progression of polycystic disease
• mice die between P14 and P17 of renal failure

homeostasis/metabolism
• the rapid increase in blood urea nitrogen level is associated with the cystic enlargement of the kidneys
• at two weeks of age

Mouse Models of Human Disease
OMIM IDRef(s)
Polycystic Kidney Disease 1; PKD1 173900 J:135301