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Phenotypes Associated with This Genotype
Genotype
MGI:3795669
Allelic
Composition
Pkd1tm2Som/Pkd1tm2.1Som
Tg(Cdh16-cre)91Igr/0
Genetic
Background
involves: C57BL/6 * ICR * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pkd1tm2.1Som mutation (0 available); any Pkd1 mutation (68 available)
Pkd1tm2Som mutation (0 available); any Pkd1 mutation (68 available)
Tg(Cdh16-cre)91Igr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die between P14 and P17 of renal failure

renal/urinary system
• at P7, proliferation of the cyst lining cells in the kidney is increased compared to in wild-type mice
• an increased kidney weight to body weight ratio is observed at day 4 and increases rapidly thereafter
• mice exhibit a rapid progression of polycystic disease
• mice die between P14 and P17 of renal failure

homeostasis/metabolism
• the rapid increase in blood urea nitrogen level is associated with the cystic enlargement of the kidneys
• at two weeks of age

Mouse Models of Human Disease
OMIM ID Ref(s)
Polycystic Kidney Disease 1; PKD1 173900 J:135301


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory