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Phenotypes Associated with This Genotype
Genotype
MGI:3795669
Allelic
Composition
Pkd1tm2Som/Pkd1tm2.1Som
Tg(Cdh16-cre)91Igr/0
Genetic
Background
involves: C57BL/6 * ICR * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pkd1tm2.1Som mutation (0 available); any Pkd1 mutation (153 available)
Pkd1tm2Som mutation (0 available); any Pkd1 mutation (153 available)
Tg(Cdh16-cre)91Igr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die between P14 and P17 of renal failure

renal/urinary system
• at P7, proliferation of the cyst lining cells in the kidney is increased compared to in wild-type mice
• mice exhibit a rapid progression of polycystic disease
• an increased kidney weight to body weight ratio is observed at day 4 and increases rapidly thereafter
• mice die between P14 and P17 of renal failure

homeostasis/metabolism
• the rapid increase in blood urea nitrogen level is associated with the cystic enlargement of the kidneys
• at two weeks of age

growth/size/body
• mice exhibit a rapid progression of polycystic disease
• an increased kidney weight to body weight ratio is observed at day 4 and increases rapidly thereafter

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
polycystic kidney disease 1 DOID:0110858 OMIM:173900
J:135301


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory