Phenotypes Associated with This Genotype

Genotype
MGI:3795604

• Allelic Composition: Pkd1^tm1Som/Pkd1^tm1Som
• Genetic Background: involves: 129/Sv * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:78422 )

• 3 mice that are born die immediately after birth

embryonic lethality during organogenesis, incomplete penetrance ( J:78422 )

• mice begin to die at E12.5 and most are dead by E16.5

renal/urinary system

kidney cyst ( J:78422 )

• at E14.5, all surviving embryos exhibit diffuse hemorrhages

endocrine/exocrine glands

pancreas cyst ( J:78422 )

• at E14.5

cardiovascular system

cardiovascular system phenotype ( J:78422 )

N • unlike in Pkd2^tm1Som mice, cardiac septation is normal

hemorrhage ( J:78422 )

• at E14.5, all surviving embryos exhibit diffuse hemorrhages

growth/size/body

decreased embryo size ( J:78422 )

• 3 small and pale mice are born but die immediately

pancreas cyst ( J:78422 )

• at E14.5

kidney cyst ( J:78422 )

• at E14.5, all surviving embryos exhibit diffuse hemorrhages

homeostasis/metabolism

edema ( J:78422 )

• at E14.5, all surviving embryos are edematous

embryo

decreased embryo size ( J:78422 )

• 3 small and pale mice are born but die immediately

integument

pallor ( J:78422 )

• 3 small and pale mice are born but die immediately