Phenotypes for Rad51 Trp53 MGI:3795437 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Rad51^tm1Hst/Rad51^tm1Hst Trp53^tm1Brd/Trp53^tm1Brd
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rad51^tm1Hst mutation (0 available); any Rad51 mutation (32 available)
Trp53^tm1Brd mutation (5 available); any Trp53 mutation (237 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between somite formation and embryo turning, complete penetrance ( J:36540 )

• double mutant embryos survive longer than Rad51^tm1Hst homozygous mice; embryos appear grossly normal at E7.5, but are smaller at E8.5 and do not develop further

cellular

decreased cell proliferation ( J:36540 )

• MEFs derived from double-homozygous mice do not proliferate in culture and exhibit characteristics of cells entering premature senescence

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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