Phenotypes Associated with This Genotype

Genotype
MGI:3795357

• Allelic Composition: Pou3f2^tm1Tno/Pou3f2^tm1Tno; Pou3f3^tm1Tno/Pou3f3^tm1Tno
• Genetic Background: involves: 129S4/SvJae * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:77999 )

• expected number of double homozygotes are born, but all die within 1 hour of birth

nervous system

abnormal neuronal migration ( J:77999 )

• E14.5-born neurons occupy significantly altered positions relative to wild-type neurons; in wild-type these neurons are in layers V and VI, but in mutant cortex, the neurons remain in the intermediate zone

abnormal cortical ventricular zone morphology ( J:77999 )

• less cell proliferation is observed at E14.5 onward compared to wild-type

abnormal cerebellum development ( J:77999 )

abnormal cerebellar foliation ( J:77999 )

• less foliation observed at P0, with loosely packed Purkinje cells observed

enlarged lateral ventricles ( J:77999 )

abnormal cerebral cortex morphology ( J:77999 )

abnormal neocortex morphology ( J:77999 )

• severely affected, with marked reduction in thickness at P0

• cortical neurons have altered positioning in neocortex

abnormal stratification in cerebral cortex ( J:77999 )

• stratification of cortical neurons appears disorganized at P0

loss of cortex neurons ( J:77999 )

• upper-layer neurons are lost in mutants in late development

abnormal olfactory bulb morphology ( J:77999 )

• bulb exhibits hypoplasia

abnormal embryonic/fetal subventricular zone morphology ( J:77999 )

• reduction in proliferating cells is most severe in cortical subventricular zone (only 16.5% of wild-type cell proliferation)

cellular

abnormal neuronal migration ( J:77999 )

• E14.5-born neurons occupy significantly altered positions relative to wild-type neurons; in wild-type these neurons are in layers V and VI, but in mutant cortex, the neurons remain in the intermediate zone