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Phenotypes Associated with This Genotype
Genotype
MGI:3795127
Allelic
Composition		 Gria3tm1Dgen/Gria3tm1Dgen
Gria4spkw1/Gria4spkw1
Genetic
Background		 involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gria3tm1Dgen mutation (2 available); any Gria3 mutation (12 available)
Gria4spkw1 mutation (3 available); any Gria4 mutation (71 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
ataxia ( J:135814 )
• at 3 months of age, mice develop mild to moderate cerebellar ataxia compared to single mutant littermates
absence seizures ( J:135814 )
• double mutants have much lower incidence of spike wave discharge (SWD) than Gria4spkw1 homozygotes

nervous system
absence seizures ( J:135814 )
• double mutants have much lower incidence of spike wave discharge (SWD) than Gria4spkw1 homozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory