Phenotypes Associated with This Genotype

Genotype
MGI:3795120

• Allelic Composition: Gria4^spkw1/Gria4^spkw1
• Genetic Background: involves: C3H/HeJ * C3HeB/FeJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

absence seizures ( J:135814 )

• Background Sensitivity: when (C3H/HeJ x C3HeB/FeJ)F1 mice are backcrossed to C3H/HeJ mice to make the hybrids homozygous for this Gria4 mutation, the mutants show a much greater spike wave discharge (SWD) incidence than the original C3H/HeJ mice

• some animals show relatively low SWD incidence whereas some display very high SWD incidence

nervous system

absence seizures ( J:135814 )

• Background Sensitivity: when (C3H/HeJ x C3HeB/FeJ)F1 mice are backcrossed to C3H/HeJ mice to make the hybrids homozygous for this Gria4 mutation, the mutants show a much greater spike wave discharge (SWD) incidence than the original C3H/HeJ mice

• some animals show relatively low SWD incidence whereas some display very high SWD incidence