Phenotypes Associated with This Genotype

Genotype
MGI:3794994

• Allelic Composition: Tg(MMTV-TGFBR2)7Hlm/?; Tg(MMTVTGFA)29Rjc/?
• Genetic Background: involves: C57BL/6 * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:85799 )

• 17 of 19 mice develop mammary tumors with 5 mice having tumors with invasive characteristics

• the number of invasive tumors is significantly less than mice carrying just the Tg(MMTVTGFA)29Rjc transgene

• 15 of the 17 mice with tumors had tumors in multiple mammary glands

• tumor development occurs with a median latency of 9 months

integument

increased mammary adenocarcinoma incidence ( J:85799 )

• 17 of 19 mice develop mammary tumors with 5 mice having tumors with invasive characteristics

• the number of invasive tumors is significantly less than mice carrying just the Tg(MMTVTGFA)29Rjc transgene

• 15 of the 17 mice with tumors had tumors in multiple mammary glands

• tumor development occurs with a median latency of 9 months

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:85799 )

• 17 of 19 mice develop mammary tumors with 5 mice having tumors with invasive characteristics

• the number of invasive tumors is significantly less than mice carrying just the Tg(MMTVTGFA)29Rjc transgene

• 15 of the 17 mice with tumors had tumors in multiple mammary glands

• tumor development occurs with a median latency of 9 months