Phenotypes Associated with This Genotype

Genotype
MGI:3794764

• Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc; Nos3^tm1Unc/Nos3^tm1Unc
• Genetic Background: B6.129P2-Nos3^tm1Unc Apoe^tm1Unc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal cardiovascular system morphology ( J:60670 )

aortic sinus aneurysm ( J:60670 )

• microaneurysmal dilations in 20% of males

• sometimes involving coronary arteries

atherosclerotic lesions ( J:60670 )

• plaques larger at 4 months than in Apoe^tm1Unc homozygotes, by 182% for males and 165% for females

increased susceptibility to atherosclerosis ( J:60670 )

• plaques in descending aorta in 90% of males as opposed to 20% of Apoe^tm1Unc males

increased systemic arterial systolic blood pressure ( J:60670 )

• about 20mm higher than in Apoe^tm1Unc homozygotes

renal/urinary system

abnormal renal glomerulus morphology ( J:60670 )

• 15% of glomeruli with large lipid deposits in foam cells filling the glomeruli

• glomerular injury progresses to dystrophic calcification and glomerular loss

decreased kidney weight ( J:60670 )

• 15% lower than in Apoe^tm1Unc homozygotes

homeostasis/metabolism

increased circulating creatinine level ( J:60670 )

• 66% higher than controls