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Phenotypes Associated with This Genotype
Genotype
MGI:3794450
Allelic
Composition
Tg(Pmp22)247Ueli/0
Genetic
Background
involves: C3H * C57BL/6
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See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• Schwann cell density is increased from P21 onwards compared to in wild-type mice (J:98118)
• Schwann cell density is increased from P21 onwards compared to in wild-type mice (J:98118)
• however, Schwann cell proliferation is normal at P21 (J:98118)
• beginning at P4, Schwann cell apoptosis rates are double wild-type rates (J:98118)
• Schwann cell density is increased from P21 onwards compared to in wild-type mice (J:98118)
• Schwann cell density is increased from P21 onwards compared to in wild-type mice (J:98118)
• however, Schwann cell proliferation is normal at P21 (J:98118)
• beginning at P4, Schwann cell apoptosis rates are double wild-type rates (J:98118)
• mice exhibit almost complete amyelination (J:98118)
• mice exhibit almost complete amyelination (J:98118)

Mouse Models of Human Disease
OMIM ID Ref(s)
Charcot-Marie-Tooth Disease, Demyelinating, Type 1A; CMT1A 118220 J:98118


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory