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Phenotypes Associated with This Genotype
Genotype
MGI:3794425
Allelic
Composition		 KitlSl-28R/KitlSl-28R
Genetic
Background		 C3.101Rl-KitlSl-28R
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
KitlSl-28R mutation (0 available); any Kitl mutation (92 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
perinatal lethality, incomplete penetrance ( J:79293 )
• only 61-71% of expected numbers are observed at P1
postnatal lethality, complete penetrance ( J:79293 )
• no animals survive beyond P18

reproductive system
decreased primordial germ cell number ( J:115437 )
• primordial germ cells are severely reduced in number or absent compared to wild-type in genital ridges at E11.5

hematopoietic system
macrocytic anemia ( J:79293 )
• severe at birth
low mean erythrocyte cell number ( J:79293 )
• significantly lower than wild-type at birth

cellular
decreased primordial germ cell number ( J:115437 )
• primordial germ cells are severely reduced in number or absent compared to wild-type in genital ridges at E11.5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory