Phenotypes Associated with This Genotype

Genotype
MGI:3794423

• Allelic Composition: Kitl^Sl-36R/Kitl^Sl-36R
• Genetic Background: C3H-Kitl^Sl-36R

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased survivor rate ( J:79293 )

postnatal lethality, incomplete penetrance ( J:79293 )

• 63% of mice survive to P18; most deaths occur prior to P7

reproductive system

decreased primordial germ cell number ( J:115437 )

• moderate numbers of primordial germ cells (PGCs) are seen in genital ridges relative to wild-type and Kitl^Sl-gb homozygotes at E11.5

• at E9.5, PGC numbers in the hindgut are 44% of wild-type

abnormal primordial germ cell migration ( J:115437 )

• at E10.5, 83% of total PGCs have migrated from hindgut, compared to 93% in wild-type

decreased primordial germ cell proliferation ( J:115437 )

• proliferation indices of migratory (in mesentery and genital ridges) and postmigratory PGCs (in genital ridges) at 10.5 and 11.5 are significantly reduced compared to wild-type values (54-66% of wild-type values)

hematopoietic system

macrocytic anemia ( J:79293 )

low mean erythrocyte cell number ( J:79293 )

• significantly lower than wild-type at birth (41% of wild-type value)

decreased hematocrit ( J:79293 )

• significantly lower than wild-type at P24-25

increased mean corpuscular hemoglobin ( J:79293 )

• significantly increased compared to wild-type at P24-25

increased mean corpuscular hemoglobin concentration ( J:79293 )

• significantly increased compared to wild-type at P24-25

cellular

decreased primordial germ cell number ( J:115437 )

• moderate numbers of primordial germ cells (PGCs) are seen in genital ridges relative to wild-type and Kitl^Sl-gb homozygotes at E11.5

• at E9.5, PGC numbers in the hindgut are 44% of wild-type

abnormal primordial germ cell migration ( J:115437 )

• at E10.5, 83% of total PGCs have migrated from hindgut, compared to 93% in wild-type

decreased primordial germ cell proliferation ( J:115437 )

• proliferation indices of migratory (in mesentery and genital ridges) and postmigratory PGCs (in genital ridges) at 10.5 and 11.5 are significantly reduced compared to wild-type values (54-66% of wild-type values)