Phenotypes Associated with This Genotype

Genotype
MGI:3794419

• Allelic Composition: Kitl^Sl-22R/Kitl^Sl-22R
• Genetic Background: C3H-Kitl^Sl-22R

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:79293 )

• no animals survive beyond P18

perinatal lethality, incomplete penetrance ( J:79293 )

• only 61-71% of expected numbers are observed at P1

prenatal lethality, incomplete penetrance ( J:79293 )

reproductive system

decreased primordial germ cell number ( J:115437 )

• primordial germ cells are severely reduced in number or absent compared to wild-type in genital ridges at E11.5

hematopoietic system

macrocytic anemia ( J:79293 )

• severe at birth

low mean erythrocyte cell number ( J:79293 )

• significantly lower than wild-type at birth (20% of wild-type value)

cellular

decreased primordial germ cell number ( J:115437 )

• primordial germ cells are severely reduced in number or absent compared to wild-type in genital ridges at E11.5