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Phenotypes Associated with This Genotype
Genotype
MGI:3794207
Allelic
Composition
Tg(ACTA1-Ar)141Kyjo/0
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• female mice treated with normal male levels of testosterone die after 9 days of treatment
• very few male mice survive to weaning
• male mice exhibit reduced viability at birth
• however, treatment with flutamide enhances male perinatal survival

muscle
• male mice exhibit atrophic and hypertrophic fibers, internal myonuclei, fiber splitting, altered myofibrillar organization and an overall increase in oxidative metabolism
• however, no inflammation is present in muscles and female mice treated with normal male levels of testosterone fail to exhibit muscle loss
• male mice exhibit decreased muscle fiber number by half in the extensor digitorum longus compared to in wild-type mice
• in male mice
• in male mice

behavior/neurological
• male mice and female mice treated with normal male levels of testosterone exhibit decreased motor function that precedes loss of body weight in the case of the females
• however, castration of males improves motor function
• in male mice

nervous system
• male mice exhibit fewer L5 motor axons than in wild-type mice without neuron loss

growth/size/body
• in male mice and female mice treated with normal male levels of testosterone

skeleton
• in male mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Kennedy's disease DOID:0060161 OMIM:313200
J:127205


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory