Phenotypes Associated with This Genotype

Genotype
MGI:3794074

• Allelic Composition: Grhl3^ct/?; Vangl2^Lp/Vangl2⁺
• Genetic Background: involves: A * GFF

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal astrocyte morphology ( J:125330 )

• at E16.5 and E18.5 mice with meningomyelocele display increased astrocyte staining compared to in wild-type mice

meningomyelocele ( J:125330 )

• mice exhibit meningomyelocele

abnormal spinal cord morphology ( J:125330 )

• in mice with meningomyelocele, the dorsal region of the neural tube lays laterally to the ventral horn and the dorsal white matter is moved into a ventrolateral position unlike in wild-type mice

• at E16.5, the number of neuronal cells in the meningomyelocele placode is decreased compared to in wild-type mice

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:125330 )

• mice exhibit meningomyelocele with hypotonic hindlimbs with spontaneous and extensive movement of the hip and knee joints but only slight movement at the ankle joints

• mice do not display coordination between fore- and hindlimbs

• mice occasionally exhibit plantar steps that demonstrate the ability to support their body weight

growth/size/body

decreased fetal weight ( J:125330 )

• mice with meningomyelocele exhibit reduced fetal weight

skeleton

meningomyelocele ( J:125330 )

• mice exhibit meningomyelocele

embryo

meningomyelocele ( J:125330 )

• mice exhibit meningomyelocele

cellular

abnormal astrocyte morphology ( J:125330 )

• at E16.5 and E18.5 mice with meningomyelocele display increased astrocyte staining compared to in wild-type mice