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Phenotypes Associated with This Genotype
Genotype
MGI:3794047
Allelic
Composition		 Mus81tm1Chmg/Mus81tm1Chmg
Genetic
Background		 involves: 129S5/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mus81tm1Chmg mutation (0 available); any Mus81 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:133703 )
N
• unlike mice homozygous for Mus81tm1Esse, no defects are seen in the aortic wall including the elastin layers

homeostasis/metabolism
increased physiological sensitivity to xenobiotic ( J:232402 )
• MEFs are more sensitive to mitomycin C compared to wild-type cells but less sensitive than MEFs null for Fan1

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/13/2026
MGI 6.24 		The Jackson Laboratory