Phenotypes Associated with This Genotype

Genotype
MGI:3794043

• Allelic Composition: Grhl3^ct/Grhl3^ct
• Genetic Background: GFF-Grhl3^ct

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

limbs/digits/tail

curly tail ( J:6864 )

nervous system

abnormal neural tube closure ( J:1549 , J:6246 )

• inositol deficiency in the culture medium increases the frequency of neural tube defects (J:1549)

• administration of vitamin A to mothers on day 8 of pregnancy increases the frequency of neural tube defects in homozygous ct offspring, but vitamin A administration on day 9 causes a marked decrease (J:6246)

spina bifida ( J:6864 )

exencephaly ( J:6245 , J:6864 )

• there is a great preponderance of females among exencephalic embryos (J:6245)

• rare (J:6864)

growth/size/body

fetal growth retardation ( J:6864 )

embryo

abnormal neural tube closure ( J:1549 , J:6246 )

• inositol deficiency in the culture medium increases the frequency of neural tube defects (J:1549)

• administration of vitamin A to mothers on day 8 of pregnancy increases the frequency of neural tube defects in homozygous ct offspring, but vitamin A administration on day 9 causes a marked decrease (J:6246)

spina bifida ( J:6864 )