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Phenotypes Associated with This Genotype
Genotype
MGI:3793731
Allelic
Composition		 Spi1tm3Dgt/Spi1tm3Dgt
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spi1tm3Dgt mutation (0 available); any Spi1 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased double-negative T cell number ( J:131217 )
• the number of DN3 decreased 4-fold compared to in wild-type mice
increased double-negative T cell number ( J:131217 )
• the number of DN1 T cells is increased 5-fold compared to in wild-type mice
increased granulocyte number ( J:131217 )
• the number of Gr-1+Mac1+ cells in the spleen and bone marrow is increased compared to in wild-type mice
decreased B cell number ( J:131217 )
• the number of B220+CD19+ B cells in the bone marrow and spleen is reduced compared to in wild-type mice

hematopoietic system
decreased double-negative T cell number ( J:131217 )
• the number of DN3 decreased 4-fold compared to in wild-type mice
increased double-negative T cell number ( J:131217 )
• the number of DN1 T cells is increased 5-fold compared to in wild-type mice
increased granulocyte number ( J:131217 )
• the number of Gr-1+Mac1+ cells in the spleen and bone marrow is increased compared to in wild-type mice
decreased B cell number ( J:131217 )
• the number of B220+CD19+ B cells in the bone marrow and spleen is reduced compared to in wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory