Phenotypes Associated with This Genotype

Genotype
MGI:3793426

• Allelic Composition: Bin1^tm2Gcp/Bin1⁺; Tg(Wap-cre)11738Mam/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:117330 )

• 5% of elderly animals of >1 year of age developed mammary tumors

• DMBA-treated animals developed well-differentiated tumors, characterized by high tubule formation, low mitotic indices, and limited nuclear pleomorphism

increased incidence of tumors by chemical induction ( J:117330 )

• DMBA-treated animals developed well-differentiated tumors, characterized by high tubule formation, low mitotic indices, and limited nuclear pleomorphism

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:117330 )

• DMBA-treated animals developed well-differentiated tumors, characterized by high tubule formation, low mitotic indices, and limited nuclear pleomorphism

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:117330 )

• 5% of elderly animals of >1 year of age developed mammary tumors

• DMBA-treated animals developed well-differentiated tumors, characterized by high tubule formation, low mitotic indices, and limited nuclear pleomorphism

integument

increased mammary gland tumor incidence ( J:117330 )

• 5% of elderly animals of >1 year of age developed mammary tumors

• DMBA-treated animals developed well-differentiated tumors, characterized by high tubule formation, low mitotic indices, and limited nuclear pleomorphism