Phenotypes Associated with This Genotype

Genotype
MGI:3790786

• Allelic Composition: Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
• Genetic Background: involves: C57BL/6 * NOD * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

digestive/alimentary phenotype ( J:135214 )

N • peri-islet Schwann cells are intact and surround remaining alpha-cells in contrast to control wild-type NOD mice

immune system

immune system phenotype ( J:135214 )

N

insulitis ( J:137009 )

• treatment with anti-PDCA-1, which depleted plasmocyoid dendritic cells, or 1MT, which neutralize indoleamine 2,3 dioxygenase production, increases the severity of insulitis

decreased dendritic cell number ( J:137009 )

• treatment with anti-PDCA-1 ablates the plasmocytoid dendritic cell population within the pancreatic lymph nodes

endocrine/exocrine glands

insulitis ( J:137009 )

• treatment with anti-PDCA-1, which depleted plasmocyoid dendritic cells, or 1MT, which neutralize indoleamine 2,3 dioxygenase production, increases the severity of insulitis

hematopoietic system

decreased dendritic cell number ( J:137009 )

• treatment with anti-PDCA-1 ablates the plasmocytoid dendritic cell population within the pancreatic lymph nodes