Phenotypes Associated with This Genotype

Genotype
MGI:3790694

• Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc; Hp^tm1Alev/Hp^tm1Alev
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

atherosclerotic lesions ( J:134942 )

• iron deposition in atherosclerotic lesions is almost two times greater than what is observed in mice that are homozygotes for just the Apoe^tm1Unc allele

• there is also increased amounts of oxidized lipids and proteins occurring in the plaques

immune system

abnormal macrophage chemotaxis ( J:134942 )

• 50% more macrophages are found in atherosclerotic lesions than in mice that are homozygous for just the Apoe^tm1Unc allele

cellular

abnormal macrophage chemotaxis ( J:134942 )

• 50% more macrophages are found in atherosclerotic lesions than in mice that are homozygous for just the Apoe^tm1Unc allele

hematopoietic system

abnormal macrophage chemotaxis ( J:134942 )

• 50% more macrophages are found in atherosclerotic lesions than in mice that are homozygous for just the Apoe^tm1Unc allele