Phenotypes Associated with This Genotype

Genotype
MGI:3790600

• Allelic Composition: Tom1l2^Gt(XG909)Byg/Tom1l2⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal fear/anxiety-related behavior ( J:133892 )

• heterozygotes show increased freezing response

increased vertical activity ( J:133892 )

• heterozygotes show increased rearing behavior in the open field at 10, 20, and 30 weeks of age but not at 5 weeks

increased locomotor activity ( J:133892 )

• a higher proportion of heterozygotes than wild-type exhibit wild running

immune system

enlarged spleen ( J:133892 )

increased susceptibility to infection ( J:133892 )

• eye infections

hematopoietic system

enlarged spleen ( J:133892 )

neoplasm

increased tumor incidence ( J:133892 )

• mutants exhibit a variety of tumors, including skin, lung, and kidney tumors, soft tissue mass in the vulva, lachrymal glad enlargement, ovarian cysts and dark mass on prostate

increased prostate gland tumor incidence ( J:133892 )

♂

increased skin tumor incidence ( J:133892 )

increased lung tumor incidence ( J:133892 )

vision/eye

abnormal cornea morphology ( J:133892 )

• corneal ulcers

abnormal eye distance/ position ( J:133892 )

• ocular assymmetry

exophthalmos ( J:133892 )

adipose tissue

increased total body fat amount ( J:133892 )

• 3% of mutants develop excess fat deposition in the abdomen

nervous system

hydrocephaly ( J:133892 )

respiratory system

increased lung tumor incidence ( J:133892 )

emphysema ( J:133892 )

skeleton

kyphosis ( J:133892 )

endocrine/exocrine glands

increased prostate gland tumor incidence ( J:133892 )

♂

ovary cyst ( J:133892 )

♀

reproductive system

increased prostate gland tumor incidence ( J:133892 )

♂

ovary cyst ( J:133892 )

♀

integument

skin lesions ( J:133892 )

• heterozygotes exhibit gross inflammatory lesions of the skin

spontaneous skin ulceration ( J:133892 )

increased skin tumor incidence ( J:133892 )

growth/size/body

ovary cyst ( J:133892 )

♀

enlarged spleen ( J:133892 )