Analysis Tools
mortality/aging
| N |
• more than half of the mice survive past weaning, are fertile and nurture their offspring normally
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• some mutants are found dead prior to weaning age
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growth/size/body
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• surviving mutants weigh less than wild-type littermates
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• surviving mutants (adults) are smaller than littermates
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nervous system
| N |
• cerebellar hemisphere development and cytoarchitecture of cerebellum are essentially normal
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• at E12.5, neuroepithelium of medial cerebellar anlage is thinner than in wild-type with abnormal indents found in the ventricular layer
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• at E10.5, mesencephalon is expanded caudally and alar plate of r1 is significantly reduced
• medial region of cerebellar primordium is reduced in size from E12.5 to 18.5
• increased cell proliferation is observed in indents into ventricular layer, resulting in small cell aggregates in ventricular layer at E14.5; large cell aggregates are observed in medial cerebella of mutants at E18.5
• however, no cell aggregates are seen in cerebella of 8-week old mutants
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• foliation pattern is disrupted in adults
• in adult mutants all lobules are reduced in size to varying extents with lobules V and IX less affected
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• at E10.5, the mesencephalon is expanded caudally
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• at E9.5, isthmic constriction dividing the mesencephalon and rhombomere 1 (r1) at dorsal midline is less prominent than in wild-type
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• proliferation in the medial region of the cerebellum is reduced compared to wild-type
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embryo
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• at E12.5, neuroepithelium of medial cerebellar anlage is thinner than in wild-type with abnormal indents found in the ventricular layer
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