Phenotypes Associated with This Genotype

Genotype
MGI:3789701

• Allelic Composition: Ppm1l^tm1Dgen/Ppm1l^tm1Dgen
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

increased body weight ( J:134171 )

• increased body weight at all time points measured between 11 and 25 weeks of age

• at 21 weeks of age mice weigh 19.3% more than wild-type controls

homeostasis/metabolism

increased circulating glucose level ( J:134171 )

• 11.5% increase in basal glucose levels in males at 21 weeks of age

decreased circulating free fatty acids level ( J:134171 )

• at 29 weeks of age

improved glucose tolerance ( J:134171 )

• decreased area under the curve in males, but not females, at 21 weeks of age

• at the 30 min time point, insulin levels are increased by 100% in males and females compared to wild-type controls

adipose tissue

increased total body fat amount ( J:134171 )

• at 20 weeks of age total fat mass is increased by 46.7% compared to wild-type controls

cardiovascular system

increased systemic arterial blood pressure ( J:134171 )

• at 25 weeks of age