Phenotypes Associated with This Genotype

Genotype
MGI:3789478

• Allelic Composition: Lama2^dy/Lama2^dy
• Genetic Background: involves: 129P1/ReJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:102959 )

• only 66% of mice survive the 24 week experiment compared to 86% of C3^tm1Hrc Lama2^dy homozygotes

muscle

skeletal muscle interstitial fibrosis ( J:102959 )

dystrophic muscle ( J:102959 )

abnormal muscle physiology ( J:102959 )

• mice display hindlimb contractures

muscle weakness ( J:102959 )

• forelimb strength is decreased compared to in C3^tm1Hrc Lama2^dy homozygotes

growth/size/body

postnatal growth retardation ( J:102959 )

• compared to C3^tm1Hrc Lama2^dy homozygotes

immune system

increased IgG level ( J:102959 )

• mice exhibit increased deposition of IgG in muscles compared to in wild-type mice

increased IgM level ( J:102959 )

• mice exhibit increased deposition of IgM in muscles compared to in wild-type mice and C3^tm1Hrc Lama2^dy homozygotes

skeleton

scoliosis ( J:102959 )

• unlike C3^tm1Hrc Lama2^dy homozygotes

hematopoietic system

increased IgG level ( J:102959 )

• mice exhibit increased deposition of IgG in muscles compared to in wild-type mice

increased IgM level ( J:102959 )

• mice exhibit increased deposition of IgM in muscles compared to in wild-type mice and C3^tm1Hrc Lama2^dy homozygotes