Phenotypes Associated with This Genotype

Genotype
MGI:3789477

• Allelic Composition: C3^tm1Hrc/C3^tm1Hrc; Lama2^dy/Lama2^dy
• Genetic Background: either: (involves: 129S2/SvPas * 129P1/ReJ) or (involves: 129X1/SvJ * 129P1/ReJ)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

extended life span ( J:102959 )

• 86% of mice survive the 24 week experiment compared to only 66% of Lama2^dy homozygotes

muscle

abnormal skeletal muscle morphology ( J:102959 )

• fewer macrophages are found within muscles compared to in Lama2^dy homozygotes

skeletal muscle interstitial fibrosis ( J:102959 )

dystrophic muscle ( J:102959 )

behavior/neurological

abnormal physical strength ( J:102959 )

• mice exhibit 25% to 20% greater forelimb strength than Lama2^dy homozygotes

growth/size/body

increased body weight ( J:102959 )

• compared to Lama2^dy homozygotes

immune system

increased IgG level ( J:102959 )

• mice exhibit increased deposition of IgG in muscles compared to in wild-type mice

decreased IgM level ( J:102959 )

• mice exhibit reduce deposition of IgM in muscles compared to in Lama2^dy homozygotes

increased IgM level ( J:102959 )

• mice exhibit increased deposition of IgM in muscles compared to in wild-type mice

hematopoietic system

increased IgG level ( J:102959 )

• mice exhibit increased deposition of IgG in muscles compared to in wild-type mice

decreased IgM level ( J:102959 )

• mice exhibit reduce deposition of IgM in muscles compared to in Lama2^dy homozygotes

increased IgM level ( J:102959 )

• mice exhibit increased deposition of IgM in muscles compared to in wild-type mice