Phenotypes for En1 En2 MGI:3789311 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	En1^tm5(en)Alj/En1^tm5(en)Alj En2^tm2Alj/En2⁺
Genetic Background	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Swiss Webster

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
En1^tm5(en)Alj mutation (0 available); any En1 mutation (32 available)
En2^tm2Alj mutation (0 available); any En2 mutation (104 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:134516 )

• about half of the expected number of mutants survive to adulthood

nervous system

decreased inferior colliculus size ( J:134516 )

• reduced in size in surviving adults

abnormal cerebellum anterior vermis morphology ( J:134516 )

• vermis displays fused folia, and folia I, II, and III are smaller than normal in adults

abnormal cerebellum posterior vermis morphology ( J:134516 )

• subregion VIII (posterior vermis) is not present in adults

small cerebellum ( J:134516 )

• in adults, reduced in overall size by one-third relative to controls

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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