Phenotypes Associated with This Genotype

Genotype
MGI:3789201

• Allelic Composition: Nos1^tm1Plh/Nos1^tm1Plh; Nos2^tm1Mrl/Nos2^tm1Mrl
• Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased survivor rate ( J:100308 )

• 60-80% survival rate at 10 months of age

premature death ( J:100308 )

• about 20-40% die before 10 months of age

reproductive system

reduced fertility ( J:100308 )

• slight reduction in the number of offspring produced from breeding pairs

homeostasis/metabolism

increased blood osmolality ( J:100308 )

• plasma osmolality is increased

increased blood urea nitrogen level ( J:100308 )

decreased urine sodium level ( J:100308 )

decreased urine osmolality ( J:100308 )

renal/urinary system

decreased urine sodium level ( J:100308 )

decreased urine osmolality ( J:100308 )

polyuria ( J:100308 )

behavior/neurological

polydipsia ( J:100308 )