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Phenotypes Associated with This Genotype
Genotype
MGI:3789190
Allelic
Composition
Nos1tm1Plh/Nos1tm1Plh
Nos2tm1Mrl/Nos2tm1Mrl
Nos3tm1Plh/Nos3tm1Plh
Genetic
Background
involves: 129S4/SvJae * 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nos1tm1Plh mutation (3 available); any Nos1 mutation (11 available)
Nos2tm1Mrl mutation (4 available); any Nos2 mutation (12 available)
Nos3tm1Plh mutation (1 available); any Nos3 mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Renal tubular apoptosis, regeneration, glomerulosclerosis and glomerular thrombus formation in Nos1tm1Plh/Nos1tm1Plh Nos2tm1Mrl/Nos2tm1Mrl Nos3tm1Plh/Nos3tm1Plh mice

mortality/aging
• only 3 of 13 mutants survive to 10 months of age (J:100308)
• only 3 of 13 mutants survive to 10 months of age (J:100308)
• only 3 of 13 mutants survive to 10 months of age (J:100308)
• only 3 of 13 mutants survive to 10 months of age (J:100308)

reproductive system
• the number of offspring produced from breeding pairs is significantly smaller than in wild-type (J:100308)
• the number of offspring produced from breeding pairs is significantly smaller than in wild-type (J:100308)

cardiovascular system
• all mutants that die show wall thickening, perivascular fibrosis, and adventitial mast cell infiltration of the coronary arteries (J:100308)
• all mutants that die show wall thickening, perivascular fibrosis, and adventitial mast cell infiltration of the coronary arteries (J:100308)
• glomerular thrombus formation (J:100308)
• glomerular thrombus formation (J:100308)
• 2 mutants that die within 10 months of age, have pulmonary and liver congestion (J:100308)
• 2 mutants that die within 10 months of age, have pulmonary and liver congestion (J:100308)
• in 2 mutants that die within 10 months of age (J:100308)
• in 2 mutants that die within 10 months of age (J:100308)
• in 2 mutants that die within 10 months of age (J:100308)
• in 2 mutants that die within 10 months of age (J:100308)
• heart rate is significantly lower than in wild-type, but similar to that of single Nos3 homozygotes, double Nos1/Nos3 homozygotes, and double Nos2/Nos3 homozygotes (J:100308)
• heart rate is significantly lower than in wild-type, but similar to that of single Nos3 homozygotes, double Nos1/Nos3 homozygotes, and double Nos2/Nos3 homozygotes (J:100308)
• hypertension is similar to single Nos3 homozygotes, double Nos1/Nos3 homozygotes, and double Nos2/Nos3 homozygotes (J:100308)
• hypertension is similar to single Nos3 homozygotes, double Nos1/Nos3 homozygotes, and double Nos2/Nos3 homozygotes (J:100308)
• systolic blood pressure is significantly higher in mutants than wild-type under conscious conditions (J:100308)
• systolic blood pressure is significantly higher in mutants than wild-type under conscious conditions (J:100308)
• the two mutants with pulmonary and liver congestion and acute renal tubular necrosis exhibit acute circulatory failure (J:100308)
• the two mutants with pulmonary and liver congestion and acute renal tubular necrosis exhibit acute circulatory failure (J:100308)

homeostasis/metabolism
• glomerular thrombus formation (J:100308)
• glomerular thrombus formation (J:100308)
• plasma concentrations of creatinine tend to be higher (J:100308)
• plasma concentrations of creatinine tend to be higher (J:100308)
• plasma osmolality is increased (J:100308)
• plasma osmolality is increased (J:100308)
• plasma concentrations of urea nitrogen are higher (J:100308)
• plasma concentrations of urea nitrogen are higher (J:100308)
• serum concentration is increased (J:150159)
• serum concentration is increased (J:150159)
• mutants exhibit only 2.4% and 3.6% of normal plasma and urinary NO levels, respectively (J:100308)
• mutants exhibit only 2.4% and 3.6% of normal plasma and urinary NO levels, respectively (J:100308)
• renal prostacyclin levels are significantly higher in 1 week old mutants than in wild-type (J:100308)
• renal prostacyclin levels are significantly higher in 1 week old mutants than in wild-type (J:100308)

renal/urinary system
• glomerular thrombus formation (J:100308)
• renal tubular lesions are seen predominantly in distal and collecting tubules than in proximal tubules (J:100308)
• glomerular thrombus formation (J:100308)
• renal tubular lesions are seen predominantly in distal and collecting tubules than in proximal tubules (J:100308)
• glomerular thrombus formation (J:100308)
• glomerular thrombus formation (J:100308)
• 2 mutants that die within 10 months of age have acute renal tubular necrosis (J:100308)
• 2 mutants that die within 10 months of age have acute renal tubular necrosis (J:100308)
• renal responsiveness to the anti-diuretic hormone, vasopressin, is reduced compared to wild-type, although central vasopressin release in unchanged (J:100308)
• impaired renal cAMP production (J:100308)
• renal responsiveness to the anti-diuretic hormone, vasopressin, is reduced compared to wild-type, although central vasopressin release in unchanged (J:100308)
• impaired renal cAMP production (J:100308)
• hypotonic polyuria (J:100308)
• hypotonic polyuria (J:100308)

behavior/neurological

digestive/alimentary system
• pyloric sphincter hypertrophy (J:100308)
• pyloric sphincter hypertrophy (J:100308)
• 3 of 5 mutants show enlargement of the stomach (J:100308)
• 3 of 5 mutants show enlargement of the stomach (J:100308)

liver/biliary system
• in 2 mutants that die within 10 months of age (J:100308)
• in 2 mutants that die within 10 months of age (J:100308)

respiratory system
• in 2 mutants that die within 10 months of age (J:100308)
• in 2 mutants that die within 10 months of age (J:100308)

skeleton
• at all time points (J:150159)
• increases slightly at 12 weeks of age (J:150159)
• at all time points (J:150159)
• increases slightly at 12 weeks of age (J:150159)
• trabecular bone in the proximal tibia is increased (J:150159)
• trabecular bone in the proximal tibia is increased (J:150159)
• increased osteoclast function (J:150159)
• higher in females than in males (J:150159)
• increased osteoclast function (J:150159)
• higher in females than in males (J:150159)
• bone formation rate and mineral apposition rate are increased (J:150159)
• higher in females than in males (J:150159)
• bone formation rate and mineral apposition rate are increased (J:150159)
• higher in females than in males (J:150159)

hematopoietic system
• increased osteoclast function (J:150159)
• higher in females than in males (J:150159)
• increased osteoclast function (J:150159)
• higher in females than in males (J:150159)

immune system
• increased osteoclast function (J:150159)
• higher in females than in males (J:150159)
• increased osteoclast function (J:150159)
• higher in females than in males (J:150159)

muscle
• pyloric sphincter hypertrophy (J:100308)
• pyloric sphincter hypertrophy (J:100308)

cellular

Mouse Models of Human Disease
OMIM ID Ref(s)
Diabetes Insipidus, Nephrogenic, Autosomal 125800 J:100308


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory