Phenotypes Associated with This Genotype

Genotype
MGI:3789188

• Allelic Composition: Nba10^NZB/Nba10^NZB; Tg(Tnfsf13b)1Fma/0
• Genetic Background: involves: C57BL/6 * DBA/2J * NZB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased B cell number ( J:134128 )

• increased total splenic B cell numbers

increased marginal zone B cell number ( J:134128 )

increased IgG level ( J:134128 )

• increased total serum IgG antibodies

increased IgM level ( J:134128 )

• increased total serum IgM antibodies

increased susceptibility to systemic lupus erythematosus ( J:134128 )

• increased serum IgG and IgM antibodies

• increased incidence of glomerulonephritis by 3 months of age

increased anti-chromatin antibody level ( J:134128 )

increased anti-double stranded DNA antibody level ( J:134128 )

• increased serum IgG anti-dsDNA Abs shows positive correlation to glomerulonephritis severity

glomerulonephritis ( J:134128 )

• increased glomerulonephritis incidence at 3 months of age

renal/urinary system

glomerulonephritis ( J:134128 )

• increased glomerulonephritis incidence at 3 months of age

hematopoietic system

increased B cell number ( J:134128 )

• increased total splenic B cell numbers

increased marginal zone B cell number ( J:134128 )

increased IgG level ( J:134128 )

• increased total serum IgG antibodies

increased IgM level ( J:134128 )

• increased total serum IgM antibodies