Phenotypes Associated with This Genotype

Genotype
MGI:3789134

• Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc; Il1rn^tm1Dih/Il1rn^tm1Dih
• Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:132570 )

• increased death rate on a high cholesterol diet

homeostasis/metabolism

decreased circulating cholesterol level ( J:132570 )

• significantly reduced plasma cholesterol levels relative to Apoe^tm1Unc homozygous controls on a normal diet

growth/size/body

decreased body weight ( J:132570 )

• relative to singly homozyous Apoe^tm1Unc

immune system

abnormal macrophage chemotaxis ( J:132570 )

• massive infiltration of macrophage in the aortic arch

cardiovascular system

cardiovascular system phenotype ( J:132570 )

N • no intimal thickening occurs on a high cholesterol diet

abnormal aorta elastic tissue morphology ( J:132570 )

• elastic lamina in the media of the aortic root is destroyed

abnormal coronary artery morphology ( J:132570 )

• elastic lamina in the media of the coronary arteries is destroyed

cellular

abnormal macrophage chemotaxis ( J:132570 )

• massive infiltration of macrophage in the aortic arch

hematopoietic system

abnormal macrophage chemotaxis ( J:132570 )

• massive infiltration of macrophage in the aortic arch