Phenotypes Associated with This Genotype

Genotype
MGI:3789132

• Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc; Tg(CAG-IL1RN)2Cga/?
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/1 * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

decreased susceptibility to atherosclerosis ( J:132570 )

• atherosclerotic lesions in the aortic root are reduced by 40% relative to Apoe^tm1Unc single homozygotes

• 67% reduction in the descending aorta

• reduced susceptibility in the aortic arch

immune system

decreased circulating serum amyloid protein level ( J:132570 )

• reduced levels of serum Amyloid A

homeostasis/metabolism

decreased circulating serum amyloid protein level ( J:132570 )

• reduced levels of serum Amyloid A