Phenotypes for Tg(ITGAM-HBEGF/EGFP)34Lan MGI:3789082 MGI Mouse

increased neutrophil cell number ( J:95141 )

• the number of neutrophils isolated from the peritoneum is doubled 24 hours after injection with diphtheria toxin

abnormal macrophage morphology ( J:95141 )

• bone marrow derived macrophages express human diphtheria toxin receptor

decreased macrophage cell number ( J:95141 )

• 24 hours after one injection of diphtheria toxin, peritoneal macrophages and blood monocytes are reduced by 4-fold

• peritoneal macrophages are eliminated after two injections of diphtheria toxin

• scar associated macrophages found in mouse model of hepatic fibrosis are significantly reduced after diphtheria toxin treatment

decreased susceptibility to injury ( J:131371 )

• following administration of diphtheria toxin, mice exhibit less renal fibrosis following unilateral ureter obstruction compared to wild-type mice

abnormal kidney physiology ( J:131371 )

• following administration of diphtheria toxin, mice exhibit less renal fibrosis following unilateral ureter obstruction compared to wild-type mice

liver fibrosis ( J:95141 )

• fibrosis induced by chemical injury has less elastin, collagen III and other collagen components associated with it when mice are depleted of macrophages by diphtheria toxin

• there is also a reduction in activated hepatic stellate cells associated with the liver injuries

• there is a reduced number of proliferating and apoptotic cells associated with the scars induced by chemical injury in mice depleted of macrophages

• when macrophages are depleted during the recovery phase of the hepatic fibrosis model, there is very little attenuation in perisinusoidal fibrosis