Phenotypes Associated with This Genotype

Genotype
MGI:3789028

• Allelic Composition: Il18^tm1Aki/Il18^tm1Aki
• Genetic Background: B6.129P2-Il18^tm1Aki

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

impaired neutrophil chemotaxis ( J:125285 )

• less numbers of neutrophils are recruited to the lung both 6- and 24 hours after infection with Haemophilus influenzae

increased susceptibility to induced colitis ( J:173245 )

• mice exhibit increased susceptibility to dextran sodium sulfate (DSS)-induced colitis compared with similarly treated wild-type mice

• mice transmit increased susceptibility to DSS-induced colitis to co-housed wild-type mice

increased susceptibility to bacterial infection ( J:125285 )

• bacterial counts in the lung are 20-fold higher one day after infection with Haemophilus influenzae

• there is less inflammation present in the lungs 6- and 24- hours after infection with histological scores significantly reduced compared to wild-type mice

• mice are able to clear infection from the lungs 10 days after infection, which is similar to wild-type mice

digestive/alimentary system

abnormal gut flora balance ( J:173245 )

• mice and co-housed wild-type mice exhibit expanded bacterial phylotypes compared with wild-type mice

increased susceptibility to induced colitis ( J:173245 )

• mice exhibit increased susceptibility to dextran sodium sulfate (DSS)-induced colitis compared with similarly treated wild-type mice

• mice transmit increased susceptibility to DSS-induced colitis to co-housed wild-type mice

cellular

impaired neutrophil chemotaxis ( J:125285 )

• less numbers of neutrophils are recruited to the lung both 6- and 24 hours after infection with Haemophilus influenzae

hematopoietic system

impaired neutrophil chemotaxis ( J:125285 )

• less numbers of neutrophils are recruited to the lung both 6- and 24 hours after infection with Haemophilus influenzae