Phenotypes for Lgals1 Myf5 MGI:3789015 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Lgals1^tm1Rob/Lgals1^tm1Rob Myf5^tm2Pas/Myf5⁺
Genetic Background	involves: 129S/SvEv * 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lgals1^tm1Rob mutation (5 available); any Lgals1 mutation (20 available)
Myf5^tm2Pas mutation (0 available); any Myf5 mutation (17 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

delayed muscle development ( J:119480 )

• mice exhibit a delay in muscle development

• cultured myoblasts exhibit impaired fusion compared to in wild-type myoblasts

abnormal skeletal muscle fiber morphology ( J:119480 )

• myonuclear numbers are decreased

decreased skeletal muscle fiber diameter ( J:119480 )

• adult mice exhibit a 22% reduction in muscle fiber diameter

delayed skeletal muscle regeneration ( J:119480 )

• increase of medium diameter fiber class is delayed after cardiotoxin injury and small tibialis anterior (TA) muscle fibers are prominent up to day 21, whereas large fibers are rarely observed

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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