Analysis Tools
immune system
| N |
• brain, liver, kidney, lung, and large intestines show no obvious leukocyte infiltration
|
|
• the mean insulitis scores of 9 week old females is the same in transgenic and non-transgenic NOD controls and three females surviving to 8 to 12 weeks of age developed overt type 1 diabetes
|
 |
• occasionally found
|
|
• Background Sensitivity: approximately 3 fold and 2 fold reduction in the proportion of splenic CD4<+> and CD8<+> T cells respectively and increased proportions of splenic B cells, splenic macrophages and dendritic cells, and splenic granulocytes
|
|
• CD4 T cells activated under Th1 priming conditions produce 10 fold less interferon gamma than controls upon secondary anti-CD3 stimulation
• splenic T cells stimulated with anti-CD3 produce very little interferon gamma upon secondary stimulation relative to NOD controls
|
|
• Background Sensitivity: On the NOD background, but not the C57BL/6 background, CD4 T cells activated under Th2 priming conditions product 10 fold less IL4 than controls upon secondary anti-CD3 restimulation
• splenic T cells stimulated with anti-CD3 produce very little IL4 upon secondary stimulation relative to NOD controls
|
|
• CD4 T cells activated under Th1 priming conditions produce less TNF alpha than controls upon secondary anti-CD3 stimulation
• splenic T cells stimulated with anti-CD3 produce very little tumor necrosis factor alpha upon secondary stimulation relative to NOD controls
|
|
• Background Sensitivity: a CD8<+> T cell dependent lethal paralytic syndrome develops before 10 weeks of age associated with a massive leukocytic inflammatory response initiating exterior to the lumbar reion of the spinal column and progressing toward the cervical region and into the peripheral limbs. Destruction of muscle, but not peripheral nerve tissue, is seen
• Background Sensitivity: this paraspinal myositis develops in all transgene carriers but with faster kinetics in females than in males
• Background Sensitivity: infiltration of macrophages, CD8<+> T cells and a small number of CD4<+> T cells, but not B cells or granulocytes are found in the myositis lesions; depletion of CD8<+> T cells via injection of anti-CD8 antibodies can prevent disease onset, whereas injection with anti-CD4 antibodies only slightly delays onset
• Background Sensitivity: splenocytes from paralytic carriers transfer the disease to NOD-Prkdcscid hosts proving autoimmune-mediated myositis
|
muscle
|
• Background Sensitivity: a CD8<+> T cell dependent lethal paralytic syndrome develops before 10 weeks of age associated with a massive leukocytic inflammatory response initiating exterior to the lumbar reion of the spinal column and progressing toward the cervical region and into the peripheral limbs. Destruction of muscle, but not peripheral nerve tissue, is seen
• Background Sensitivity: this paraspinal myositis develops in all transgene carriers but with faster kinetics in females than in males
• Background Sensitivity: infiltration of macrophages, CD8<+> T cells and a small number of CD4<+> T cells, but not B cells or granulocytes are found in the myositis lesions; depletion of CD8<+> T cells via injection of anti-CD8 antibodies can prevent disease onset, whereas injection with anti-CD4 antibodies only slightly delays onset
• Background Sensitivity: splenocytes from paralytic carriers transfer the disease to NOD-Prkdcscid hosts proving autoimmune-mediated myositis
|
hematopoietic system
|
• Background Sensitivity: approximately 3 fold and 2 fold reduction in the proportion of splenic CD4<+> and CD8<+> T cells respectively and increased proportions of splenic B cells, splenic macrophages and dendritic cells, and splenic granulocytes
|
endocrine/exocrine glands
|
• the mean insulitis scores of 9 week old females is the same in transgenic and non-transgenic NOD controls and three females surviving to 8 to 12 weeks of age developed overt type 1 diabetes
|
|
|
• occasionally found
|
reproductive system
|
|
• occasionally found
|
growth/size/body
weight loss
(
J:81981
)
|
• Background Sensitivity: associated with the onset of paralytic myositis
|
