Phenotypes Associated with This Genotype

Genotype
MGI:3785870

• Allelic Composition: Tg(CD2-Ifngr2)2Pbro/?
• Genetic Background: B6.Cg-Tg(CD2-Ifngr2)2Pbro

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:134448 )

N • flow cytometric analysis of thymocytes, splenocytes, and bone marrow cells indicates normal lymphocyte population distributions

abnormal T-helper 1 cell differentiation ( J:134448 )

• diminished interferon gamma production by stimulated splenocytes differentiated in vitro with Th1 polarizing cytokines

abnormal T-helper 1 physiology ( J:134448 )

• Ifngr2 is expressed from the transgene and the endogenous gene in DNP-KLH induced TH1 and TH2 clones and treatment with interferon gamma activates Stat1

• Th1 cells differentiated in vitro have a greater proliferative response to anti-CD3 in the presence of IL2

• CD4<+> splenocytes from KLH-immunized mice do not produce interferon gamma but do proliferate normally in response to antigen-specific stimulation, yet antigen-specific IgG2a are not detected after immunization and the second booster with KLH, although IgG2a and IgG1 production are normal from purified B cells stimulated with LPS and interferon gamma or interleukin 4

• increased susceptibility to Leishmania major

increased susceptibility to parasitic infection ( J:134448 )

hematopoietic system

abnormal T-helper 1 cell differentiation ( J:134448 )

• diminished interferon gamma production by stimulated splenocytes differentiated in vitro with Th1 polarizing cytokines

abnormal T-helper 1 physiology ( J:134448 )

• Ifngr2 is expressed from the transgene and the endogenous gene in DNP-KLH induced TH1 and TH2 clones and treatment with interferon gamma activates Stat1

• Th1 cells differentiated in vitro have a greater proliferative response to anti-CD3 in the presence of IL2

• CD4<+> splenocytes from KLH-immunized mice do not produce interferon gamma but do proliferate normally in response to antigen-specific stimulation, yet antigen-specific IgG2a are not detected after immunization and the second booster with KLH, although IgG2a and IgG1 production are normal from purified B cells stimulated with LPS and interferon gamma or interleukin 4

• increased susceptibility to Leishmania major