Analysis Tools
reproductive system
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• male mice exhibit bilateral papillary hyperplasia that protrudes into the lumen of the epididymis
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neoplasm
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• at 8 weeks, mice exhibit multiple hyperplastic and dysplastic nodules of the mammary epithelium infiltrating the entire mammary fat pad
• at 95 days, female mice exhibit multiple mammary tumors
female mice develop tumors by 89 days and male mice by 114 days
• female mice exhibit diffuse, polyclonal tumor masses
• tumor morphogenesis corresponds to transgene expression
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endocrine/exocrine glands
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• male mice exhibit bilateral hypertrophic serous glands with large quantities of intracytoplasmic secretions and the intermingling of hyperplastic mucous gland epithelium
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• the parotid gland of male mice weighs five times more than in wild-type mice
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• at 8 weeks, mice exhibit multiple hyperplastic and dysplastic nodules of the mammary epithelium infiltrating the entire mammary fat pad
• at 95 days, female mice exhibit multiple mammary tumors
female mice develop tumors by 89 days and male mice by 114 days
• female mice exhibit diffuse, polyclonal tumor masses
• tumor morphogenesis corresponds to transgene expression
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behavior/neurological
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• females fail to nurse
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digestive/alimentary system
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• male mice exhibit bilateral hypertrophic serous glands with large quantities of intracytoplasmic secretions and the intermingling of hyperplastic mucous gland epithelium
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• the parotid gland of male mice weighs five times more than in wild-type mice
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integument
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• at 8 weeks, mice exhibit multiple hyperplastic and dysplastic nodules of the mammary epithelium infiltrating the entire mammary fat pad
• at 95 days, female mice exhibit multiple mammary tumors
female mice develop tumors by 89 days and male mice by 114 days
• female mice exhibit diffuse, polyclonal tumor masses
• tumor morphogenesis corresponds to transgene expression
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