Phenotypes Associated with This Genotype

Genotype
MGI:3785772

• Allelic Composition: Bmpr1a^tm2.1Bhr/Bmpr1a^tm2.1Bhr; Tg(Col2a1-cre)1Bhr/?
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Skeletal abnormalities in Bmpr1b^tm1Kml/Bmpr1b^tm1Kml, Bmpr1a^tm2.1Bhr/Bmpr1a^tm2.1Bhr Tg(Col2a1-cre)1Bhr/?, and Bmpr1a^tm2.1Bhr/Bmpr1a^tm2.1Bhr Bmpr1b^tm1Kml/Bmpr1b^tm1Kml Tg(Col2a1-cre)1Bhr/? mice

mortality/aging

postnatal lethality ( J:97410 )

skeleton

decreased length of long bones ( J:97410 )

abnormal thoracic cage shape ( J:97410 )

• rib cage is flattened

small thoracic cage ( J:97410 )

• rib cage is smaller and flattened

chondrodystrophy ( J:97410 )

• generalized chondrodysplasia

delayed bone ossification ( J:97410 )

respiratory system

respiratory distress ( J:97410 )

• respiratory distress due to smaller and flattened rib cage